The Tigers host Manchester United in their first top-flight home match for almost a decade on Saturday.
“There is already a real buzz around the city and I want local businesses to make the most of it,” Campbell said.
“Whether you run a pub, restaurant, hotel, shop or you have a completely new idea, we are going to have thousands of visitors coming into Hull and a lot more attention on the city on matchdays. My message to businesses is be ambitious.”
Meanwhile, Chris Blacksell, chair of Visit Hull and East Yorkshire, said: “Hull City’s return to the Premier League is a fantastic opportunity to showcase Hull and the wider East Yorkshire region to audiences across the UK and around the world.
“We’re working with local businesses and tourism partners to ensure every fan receives a warm Yorkshire welcome, from the moment they arrive at the railway station to their time exploring our hotels, restaurants, attractions and vibrant city centre.”